FIG 3.

Activities of various antifungal combinations in the setting of suboptimal posaconazole exposures in experimental pulmonary mucormycosis. Each datum point represents the log₁₀ conidial equivalent (C.E.) lung fungal DNA. Each line represents median concentration of the treatment group. POS 10, 10 mg/kg/daily posaconazole by oral gavage (AUC/MIC, 33); DEF 10, 10 mg/kg/day deferoxamine by oral gavage; CAS 1, 1 mg/kg/day caspofungin by intraperitoneal injection; L-AMB 5, 5 mg/kg/day liposomal amphotericin B by intravenous injection; POS 80, 80 mg/kg/daily posaconazole by oral gavage (AUC/MIC, 196). Groups were analyzed using the Kruskal-Wallis test with Tukey's post hoc comparison.