TABLE 3.
Comparison of median IC50 of each antimalarial based on initial parasitic stage in P. vivax isolates
| Antimalarial | Group 1a |
Group 2a |
F test P value | ||
|---|---|---|---|---|---|
| No. of isolates | IC50b (median [IQR]) (nM) | No. of isolates | IC50b (median [IQR]) (nM) | ||
| Chloroquine | 15 | 17.0 (3.2–59.8) | 15 | 39.3 (11.5–73.7) | <0.0001 |
| Mefloquine | 13 | 24.1 (17.3–58.8) | 15 | 72.2 (37.4–169.5) | 0.644 |
| Amodiaquine | 12 | 3.7 (3.0–31.6) | 14 | 7.2 (4.6–17.5) | 0.199 |
| Quinine | 14 | 65.0 (24.8–946.2) | 14 | 209.2 (53.5–378.3) | 0.301 |
| Artesunate | 12 | 0.3 (0.1–1.0) | 14 | 1.4 (0.2–2.0) | <0.0001 |
a
Isolates with valid IC50 for each antimalarial.
b
Analysis of the median of the concentration that inhibited 50% of the maturation of the schizonts. IQR, interquartile range (25% to 75%).