TABLE 3.
Summary of DTG comparisons with and without FPV-RTV
| Plasma DTG PK parametera | DTG + FPV-RTV vs DTG alone [GLS mean ratio (90% CI)] (n = 12) |
|---|---|
| AUC0–τ | 0.651 (0.542–0.782) |
| Cmax | 0.763 (0.632–0.921) |
| Cτ | 0.510 (0.413–0.629) |
| CL/F | 1.534 (1.276–1.843) |
| t1/2 | 0.791 (0.735–0.851) |
a
AUC0–τ, area under the concentration-time curve from when the dose is administered until the end of the dosing interval; CL/F, apparent oral clearance; Cmax, maximum plasma concentration; Cτ, plasma concentration at the end of the dosing interval; t1/2, apparent terminal half-life.