FIG 4.

Cell viability of artesunate-treated mock-infected and JCPyV-infected COS-7 cells. The cellular DNA replication (A) and total metabolic activity (B) of mock-infected COS-7 cells were measured at 24, 48, 72, and 96 hpt. The cellular DNA replication (C) and total metabolic activity (D) of JCPyV-infected COS-7 cells were measured at 96 hpt (98 hpi). (E) The ATP content of metabolically active mock-infected and JCPyV-infected COS-7 cells was measured at 96 hpt (98 hpi) (for details, see Materials and Methods). The mean values ± SDs from two to three experiments are presented as the percentage of untreated cells. Each experiment was performed in 3 parallel wells.