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Determination of artesunate EC50 and CC50 by curve fitting. To determine the EC50 (blue, JCPyV load) and CC50 (red, JCPyV-infected cells, and green, mock-infected cells), the effect of increasing concentrations of artesunate on extracellular JCPyV DNA loads and on cellular DNA replication (BrdU incorporation) was analyzed by curve fitting using the XLfit program. The mean values ± SDs from three experiments are presented.
