TABLE 1.
Mutation of embA and embB in M. tuberculosis clinical strains
|
embB mutation codon substitution |
No. of strains with EMB DST resulta: |
embA mutation nucleotide substitution or deletion |
No. of strains with EMB DST resulta: |
||||
|---|---|---|---|---|---|---|---|
| Site(s) | Pattern | S | R | Site | Pattern | S | R |
| 306 | M-I | 23 | 34 | −12 | C-T | 2 | |
| −16 | C-A | 1 | |||||
| −16 | C-T | 1 | |||||
| −16 | C-G | 7 | |||||
| M-L | 6 | 10 | −11 | C-A | 2 | ||
| −12 | C-T | 1 | |||||
| −16 | C-A | 2 | |||||
| −16 | C-T | 1 | |||||
| M-V | 13 | 90 | −11 | C-A | 1 | ||
| −16 | C-T | 2 | |||||
| −16 | C-G | 1 | |||||
| 406 | G-S | 7 | 2 | −11 | C-T | 1 | |
| G-R | 1 | ||||||
| G-D | 11 | 3 | −12 | C-T | 1 | ||
| G-A | 4 | 15 | −16 | C-T | 1 | ||
| −16 | C-G | 3 | |||||
| 497 | G-C | 1 | |||||
| Q-P | 1 | ||||||
| Q-R | 3 | 7 | −16 | C-T | 1 | 1 | |
| −41 | A del | 3 | |||||
| Q-K | 1 | 5 | |||||
| 306 and 406 | M-I and G-D | 3 | |||||
| M-I and G-A | 2 | ||||||
| M-V and G-D | 2 | ||||||
| 306 and 497 | M-I and Q-F | 1 | |||||
| M-I and Q-R | 1 | ||||||
| 296 and 306 | N-I and M-I | 1 | |||||
| 304 and 306 | L-V and M-I | 1 | |||||
| 360 and 406 | V-A and G-A | 1 | |||||
| 246 | G-R | 1 | 4 | ||||
| 288 | L-V | 1 | |||||
| 296 | N-S | 4 | |||||
| 319 | Q-R | 1 | −12 | C-T | 1 | ||
| 328 | D-G | 1 | |||||
| 328 | D-F | 1 | |||||
| 328 | D-Y | 1 | 1 | ||||
| 330 | F-L | 1 | 4 | ||||
| 334 | Y-H | 1 | 0 | ||||
| 354 | D-A | 3 | 3 | −12 | C-T | 1 | |
| 380 | S-N | 1 | |||||
| 397 | P-R | 1 | |||||
| 397 | P-S | 1 | −16 | C-T | 1 | 0 | |
| 400 | N-S | 1 | |||||
| 409 | A-P | 1 | |||||
| 445 | E-R | 1 | |||||
| 446 | L-S | 1 | |||||
| 466 | L-W | 1 | |||||
| Detection region | wtb | −8 | C-T | 1 | |||
| −11 | C-A | 3 | |||||
| −12 | C-T | 1 | 9 | ||||
| −16 | C-T | 6 | |||||
| −16 | C-G | 1 | |||||
| −27 | T del | 1 | |||||
a
R, resistance; S, susceptibility.
b
wt, embB in the detection region was wild type.