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. 2014 Dec 1;7:95. doi: 10.3389/fnmol.2014.00095

FIGURE 5.

FIGURE 5

(A) EPSP slope as a function of stimulus current in slices of NPR-BΔKC (functional down-regulation of NPR-B signaling) and wild type (wt) rats. EPSP slopes recorded as mV/ms were determined between 0.5 and 2 mV. Note the greater excitability in hippocampal slices of NPR-BΔKC rats with significant differences at 0.5–2 mV stimulus current. (B) Paired-pulse facilitation as a function of interpulse interval current in slices of NPR-BΔKC (NPR-B) and wild type (wt) rats. Paired pulses as determined by the ratio of EPSP slope 2/EPSP slope 1 were recorded at 20, 25, 40, 50, 100, and 300 ms time intervals. Note the larger facilitation in slices of NPR-BΔKC rats at interpulse intervals of 20 and 25 ms. Asterisks indicate significant changes (*p < 0.05 and **p < 0.01).