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. 2014 Dec 1;8:157. doi: 10.3389/fncom.2014.00157

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Copyright © 2014 Lennon, Hecht-Nielsen and Yamazaki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spontaneously active MLI neuron models reproduce similar firing patterns as observed in vitro. (A) Trace of an isolated MLI membrane potential with spikes artificially drawn. The neuron appears to fire regularly in absence of inhibitory synaptic currents. (B) Inter-spike interval (ISI) histogram of the isolated MLI. The parameters for the gamma distribution governing the random depolarizing current injected into the neuron were chosen such that the mean firing rate and ISI coefficient of variation (CV) were similar to the example neuron shown in Hausser and Clark (1997). All simulations were run for 300 s. (C) A spike autocorrelogram of the isolated MLI showing regularity in trains of spikes. (D) Membrane potential trace of one MLI selected from the intact network of MLIs and PKJs where inhibitory synaptic currents a present. From the trace, the neuron visibly fires irregularly compared to the isolated case. (E) An inter-spike interval histogram of the same MLI. The distribution shifts rightward and becomes broader, suggesting a slower and more irregular firing pattern. (F) A spike autocorrelogram of the same MLI showing the regularity in spike trains has disappeared.