Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Dec 1;8:157. doi: 10.3389/fncom.2014.00157

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Lennon, Hecht-Nielsen and Yamazaki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Feedforward inhibition causes prolonged inter-spike intervals in the target neuron. (A) 30 membrane potential traces overlaid with first spike aligned from a single isolated PKJ. Spikes are artificially drawn. The variable ISI can be seen. (B) A model MLI was then synaptically connected to the PKJ providing feedforward inhibition and caused to fire 12 ms (marked by the black arrowhead) after the first PKJ spike. 30 membrane potential traces with the first spike aligned from the PKJ are shown. The effect of the IPSC (4 nS peak in this simulation) can be shown to increase the average ISI. (C) Histograms of ISIs in the case without feedforward inhibition (as in A) (darker shade, left histogram) and with feedforward inhibition (as in B) (lighter shade, right histogram). (D) The relationship between IPSC and ISI can be seen by varying the synaptic conductance randomly in separate trials and measuring the resulting ISI.