TABLE 2.
Compounds that suppress P. aeruginosa elastase activity measured by elastin-Congo red assays
| Chemical no. | Chemical name | Source | OD495 ratio (%)a | CFU ratio (%)b | Bioactivity |
|---|---|---|---|---|---|
| MS10 E8 | Ciprofloxacin | Synthetic | 0 | 2.00 | Antibacterial, fungicide |
| MS10 E10 | Azithromycin | Semisynthetic | 1.60 | 1.00 | Antibacterial |
| MS01-D9 | Norfloxacin | Synthetic; MK-366 | 2.30 | 0 | Antibacterial |
| MS03-A2 | Difloxacin hydrochloride | Synthetic; Abbott-56619 | 2.90 | 0 | Antibacterial, DNA gyrase inhibitor |
| MS03-H4 | Enrofloxacin | Synthetic | 3.20 | 0 | Antibacterial |
| MS04-A8 | Mitomycin | Streptomyces verticillatus; NSC-26980 | 3.30 | 0 | Antineoplastic |
| MS03-E8 | Rifaximin | Semisynthetic | 3.60 | 65.70 | Antibacterial, RNA synthesis inhibitor |
| MS03-F10 | Gemifloxacin mesylate | Synthetic; SB-265805S, LB-20304a | 3.60 | 0.00 | Antibacterial |
| MS01-E5 | Cefmenoxime hydrochloride | Synthetic; Abbott-50192 | 4.40 | 1.90 | Antibacterial |
| MS03-H11 | Acrisorcin | Synthetic | 5.60 | 14.6 | Antifungal |
| MS02-H4 | Pentetic acid | Synthetic; DTPA | 17.30 | 128.60 | Chelating agent, diagnostic aid |
| MS05-A7 | Chlortetracycline hydrochloride | Streptomyces aureofaciens | 18.30 | 1 | Antibacterial |
| MS07-B4 | Polymyxin B sulfate | Bacillus polymyxa | 20.90 | 0 | Antibacterial |
| MS06-C6 | Glucosamine hydrochloride | Polysaccharides in bacteria | 22.30 | 0 | Antiarthritic |
| MS06-C5 | Gentian violet | Synthetic | 22.60 | 80 | Antibacterial, Anthelmintic |
| MS06-D4 | Hexachlorophene | Synthetic | 23.80 | 0 | Anti-infective (topical) |
a
Relative elastase activity (OD495 ratio after treatment with compound versus vehicle control).
b
CFU ratio (CFU after treatment with compound versus vehicle control).