TABLE 1.
Susceptibilities of the New Delhi metallo-β-lactamase-producing clinical isolates and the E. coli J53 transconjugants
| Strain | Antibiotic resistance gene(s) | MIC (μg/ml)a |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMP | AMP+CLAb | TZP | CTX | CTX+CLAb | CMZ | CAZ | AZT | FEP | IPM | LVX | FOF | GEN | AMK | ||
| E. coli TK1044 | NDM-5, CTX-M-15 | >256 | >256 | >256 | >256 | >256 | 256 | >256 | >256 | >256 | 4 | 16 | 8 | 0.5 | 2 |
| E. coli J53 (NDM-5) | NDM-5 | >256 | >256 | 256 | 256 | 256 | 64 | >256 | 0.125 | 32 | 4 | ≤0.06 | 16 | 0.125 | 0.5 |
| K. pneumoniae TK1238 | NDM-1, CTX-M-15, OXA-1, RmtC | >256 | >256 | >256 | >256 | 256 | 64 | >256 | 32 | 64 | 32 | 16 | 256 | >256 | >256 |
| E. coli J53 (NDM-1) | NDM-1, RmtC | >256 | >256 | 128 | 256 | 128 | 16 | >256 | 0.25 | 16 | 4 | ≤0.06 | 32 | >256 | >256 |
| E. coli J53 | 4 | 4 | 1 | 0.125 | ≤0.06 | 2 | 0.125 | 0.125 | ≤0.06 | 0.125 | ≤0.06 | 4 | 0.125 | 0.5 | |
a
Antibiotics: AMP, ampicillin; CLA, clavulanic acid; TZP, piperacillin-tazobactam; CTX, cefotaxime; CMZ, cefmetazole; CAZ, ceftazidime; AZT, aztreonam; FEP, cefepime; IPM, imipenem; LVX, levofloxacin; FOF, fosfomycin; GEN, gentamicin; AMK, amikacin.
b
MICs were determined in the presence of clavulanic acid (4 μg/ml).