FIG 1.
(A) Chemical structure of the new CCR5 inhibitor VCH-286, a citrate salt. (B) Inhibitory effects of VCH-286 (left), MVC (middle), and VVC (right) on HIV-1BAL. (C) Inhibitory effects of VCH-286 (left), MVC (middle), and VVC (right) on HIV-1CC1/85. The core viral protein p24 was measured from the culture supernatant by commercial enzyme-linked immunoassay (PerkinElmer) at day 7 postinfection (mean ± SD from three independent experiments). *, P < 0.05 calculated by paired t test (comparing the p24 production by HIV-infected cells with each drug concentration relative to infected nontreated cells). Cell viability was assessed by the exclusion method using the Trypan blue dye.