TABLE 1.

Malaria Box hits identified by PfDGFA and PbODA

Compound ID no.	Subset	Result with 1 μM compounda:
		PfDGFA						PbODA
		Male gametocytes			Female gametocytes
		% inhibition	SEM	SMMD	% inhibition	SEM	SSMD	% inhibition	SEM	SSMD
MMV000448	Probe-like	97.47	1.33	−2.21	24.60	7.82	−17.66	96.20	1.14	−2.04
MMV085203	Probe-like	96.85	2.08	−2.13	−15.86	25.95	0.17	−14.08	4.50	1.03
MMV665827	Probe-like	92.37	3.62	−2.24	−15.24	16.94	0.28	41.89	6.91	−1.83
MMV667491	Probe-like	83.58	12.98	−0.85	27.26	10.76	−0.91	−7.36	5.55	0.01
MMV665980	Probe-like	80.70	7.91	−0.97	73.75	12.33	−0.77	14.01	21.01	−0.13
MMV666691	Probe-like	77.35	5.93	−2.54	−7.34	12.62	0.01	72.74	6.19	−1.72
MMV019918	Drug-like	74.09	11.71	−0.52	38.13	12.60	−1.19	−9.54	3.12	0.29
MMV666026	Probe-like	71.26	12.55	−0.61	−5.89	7.11	0.31	2.46	18.69	0.10
MMV665977	Probe-like	71.21	5.83	−3.32	−14.99	6.52	0.78	20.52	20.27	−0.39
MMV665878	Drug-like	70.87	1.25	−2.13	36.64	7.76	−2.02	58.53	10.06	−1.31
MMV006389	Probe-like	70.66	6.41	−0.83	11.01	11.19	−0.35	71.31	17.10	−0.91
MMV020439	Drug-like	67.37	6.35	−2.38	−15.45	11.63	0.41	78.13	5.07	−2.12
MMV007116	Drug-like	65.80	8.34	−2.05	9.93	9.76	−0.20	97.88	0.68	−2.08
MMV006457	Probe-like	63.56	10.85	−1.48	2.21	13.53	−0.02	27.95	10.34	−1.09
MMV007127	Probe-like	62.89	4.29	−0.80	8.27	6.96	−0.53	56.77	20.72	−0.68
MMV665830	Probe-like	62.29	18.19	−0.69	56.10	12.13	−1.44	−10.78	0.72	1.00
MMV645672	Probe-like	58.81	22.14	−0.65	−16.41	15.92	0.19	97.46	1.10	−1.50
MMV665972	Probe-like	54.08	17.15	−0.52	10.70	17.59	−0.15	−6.48	6.64	0.07
MMV396749	Drug-like	48.23	3.66	−0.63	24.02	17.48	−0.48	54.64	11.33	−2.16
MMV665941	Probe-like	19.70	12.32	−0.63	44.59	18.58	−0.79	62.53	11.62	−1.32

^aShown is the mean percentage of inhibition compared to the DMSO control in the PfDGFA and PbODA. The screening data set for entire library can be found in Data Sets S1 and S2 in the supplemental material. SEM, standard error of the mean; SSMD, strictly standardized mean difference. Robustness of data: <−5 or >+5, extremely strong; <−1.28 or >+1.28, moderate; <−0.5 or >+0.5, weak; <−0.25 or >+0.25, extremely weak.