TABLE 1.

BMS-791325 activity against HCV genotype 1 to 6 chimeric replicons

NS5B genotype of chimeric replicon	No. of isolates	EC50 (nM)a
		Avg	Range
1a	4	5	2.1 to 7
1b	2	7	4.5 to 9
2a	2	NAb	76 to >500
2b	2	925	450 to 1,400
3a	6	4	1 to 5.6
4a	3	6	2 to 9.3
5a	4	3	0.5 to 5.5
6a	3	30	9 to 71

^aEC₅₀s are generated from at least two independent experiments for all cell lines.

^bNA, not available.