. 2014 Dec;58(12):7164–7170. doi: 10.1128/AAC.03258-14

TABLE 2.

Determinants of the INH C_max and AUC_0–6 in daily and twice-weekly doses

Determinant	Daily dose of INH						Twice-weekly dose of INH
Determinant	n	Median C_max (mg/liter)	P value	n^b	AUC_0–6 (mg·h/liter)	P value	n	Median C_max (mg/liter)	P value	n^b	AUC_0–6 (mg·h/liter)	P value
TB comorbidity^a
DM	11	2.6	1	11	10.39	0.6	13	4.4	0.3	11	54.26	0.2
HIV	16	2.6	0.8	13	9.72	0.6	13	9.9	1	12	53.64	0.6
TB alone	32	3		27	11.05		18	8.6		16	62.45
Sex
Male	36	2.8	1	31	10.23	0.9	29	8.6	0.2	26	46.28	0.2
Female	23	2.8		20	11.1		15	21.4		13	79.71
Fasting status with therapy
Fasting	6	3.1	0.4	6	11.06	0.2	6	16.6	1	4	71.52	1
Nonfasting	25	2.1		20	6.96		9	7.7		8	53.17
Age group
18–30 yrs	22	3	0.8	20	10.61	0.6	17	9.9	0.9	15	40.51	0.7
31–40 yrs	23	2.5		18	8.77		12	7.4		10	31.45
>40 yrs	14	2.9		13	9.71		15	8.8		14	28.32
Intestinal parasites
Yes	4	2.1	0.6	3	4	0.3	5	9	0.9	5	34.81	0.9
No	53	3		46	10.12		39	8.6		34	38.65
Bacteriologically confirmed TB
Yes	44	2.8	0.6	36	9.6	1	31	9.9	0.9	26	38.9	0.6
No	15	2.5		15	9.7		13	8.6		13	19.6
Overall median	59	2.8		51	9.71		44	8.7		39	37.81

The TB comorbidity group compared the DM-TB or HIV-TB group with the TB-alone (non-HIV non-DM) group. All the variables were analyzed with the nonparametric Wilcoxon test, and the Kruskal-Wallis test was used for the age group variable.

The numbers related to the C_max are slightly different than the numbers related to the AUC, because we were unable to calculate the AUC in cases of undetectable levels or delayed absorption (according to the C_max at 6 h).