TABLE 4.
Pharmacokinetic parameters derived for a typical Plachouras patienta across studies
| Parameterb | Plachouras et al. (2) | Garonzik et al. (17) | Present study |
|---|---|---|---|
| CMS | |||
| CLCMS (ml/min) | 228 | 115.7 | 110.1 |
| VCMS (liters) | 13.5 | 15.9 | 18.2c |
| VpCMS (liters) | 28.9 | 18.7 | |
| CLRCMS (ml/min) | 84.1 | 66.4 | |
| t1/2 (h) | 2.3 | 4.5 | 1.9 |
| Colistin | |||
| 1 − fe | 0.27 | 0.40 | |
| CLcol/fm.col (ml/min) | 151.5 | 207.1 | 94.3 |
| Vcol/fm.col (liters) | 189 | 164.8 | 25.7 |
| t1/2 (h) | 14.4 | 9.2 | 3.2 |
a
With a CLCR of 82 ml/min and body weight of 80 kg.
b
CLCMS, total clearance of CMS; VCMS, volume of distribution of central compartment for CMS; VpCMS, volume of distribution of peripheral compartment for CMS; CLRCMS, renal clearance of CMS; t1/2, terminal half-life; 1 − fe, fraction of CMS not excreted unchanged in urine; CLcol, apparent clearance of colistin; Vcol, apparent volume of distribution of colistin; fm.col, fraction of CMS converted in colistin.
c
Volume for a one-compartment model.