FIG 1.

GlTIM inactivation by omeprazole. One hundred percent of the enzyme activities were fitted with the activity registered for the enzymes incubated without omeprazole (3,870 μmol min⁻¹ mg⁻¹ and 4,230 μmol min⁻¹mg⁻¹ for GlTIM and HsTIM, respectively). (A) Efficacy and species-specific inactivation of omeprazole at pH 7.0. (B) Efficiency and species-specific inactivation of acid-activated omeprazole for 1 and 3 h. Values are means ± standard deviations (SD) from at least three independent experiments. Omeprazole IC₅₀ under neutral pH conditions are shown for GlTIM (C) and HsTIM (D).