TABLE 2.
Reported vancomycin concentrations in spiked telavancin samples (phase one)
| Theoretical telavancin concn (μg/ml) | Reported vancomycin concna (% theoretical) |
|||||||
|---|---|---|---|---|---|---|---|---|
| FPIA (Integra) | EMIT |
PETIA |
CMIA |
|||||
| Olympus | P-Module | Synchron | Vista | Architect | Centaur | LC-MS | ||
| 0 | BQL | BQL | BQL | BQL | BQL | BQL | 1.3 | BQL |
| 5 | BQL | BQL | BQL | BQL | BQL | 0.2 (4.0) | 1.1 (22.0) | 5.9 (118.8) |
| 10 | BQL | BQL | BQL | BQL | BQL | 0.2 (2.0) | 2.4 (24.0) | 12.2 (122.0) |
| 20 | BQL | BQL | BQL | 8.9 (44.5) | 1.2 (6.0) | 0.5 (2.5) | 4.8 (24.0) | 23.4 (117.0) |
| 40 | 1.5 (3.75) | BQL | BQL | 16 (40.0) | 2.3 (5.8) | 0.6 (1.5) | 7.5 (18.8) | 46.3 (115.8) |
| 60 | BQL | BQL | BQL | 25.9 (43.2) | 2.4 (4.0) | 0.9 (1.5) | 15.5 (25.8) | 71.3 (118.8) |
| 100 | 1.5 (1.5) | BQL | BQL | 38.5 (38.5) | 4.6 (4.6) | 0.9 (0.9) | 25.5 (25.5) | 110.0 (110.0) |
a
BQL, below the quantitation limit.