FIG 1.

In vitro evidence that AR-12 potentiates the anti-Salmonella activity of gentamicin. (A) Structure of AR-12. a.k.a., also known as. (B) Salmonella Typhimurium-infected RAW264.7 macrophages were exposed to vehicle, AR-12 (1 μM), gentamicin (10 μg/ml), or the combination of AR-12 and gentamicin for 24 h, and the CFU values of cell lysates (intracellular bacteria; left) and culture medium (extracellular bacteria; middle) and the sum of CFU (total bacteria; right) were determined. Data are presented as means ± SD (n = 3). Statistical significance was examined using a two-tailed t test. *, P < 0.05; **, P < 0.01.