TABLE 2.

AR-12 does not enhance the accumulation of aminoglycosides in macrophages

Treatment	Minimal inhibitory titer			MIC (μg/ml)
	24 h	72 h	120 h	24 h	72 h	120 h
Mock	>1/2	>1/2	>1/2
Gentamicin (10 μg/ml)	>1/2	1/2	1/4
Gentamicin (10 μg/ml) + AR-12 (1 μM)	>1/2	1/2	1/4
Amikacin (20 μg/ml)	>1/2	1/2	1/8
Amikacin (20 μg/ml) + AR-12 (1 μM)	>1/2	1/2	1/8
Kanamycin (40 μg/ml)	>1/2	>1/2	1/4
Kanamycin (40 μg/ml) + AR-12 (1 μM)	>1/2	>1/2	1/4
Streptomycin (80 μg/ml)	>1/2	>1/2	1/2
Streptomycin (80 μg/ml) + AR-12 (1 μM)	>1/2	>1/2	1/2
Mock lysate + gentamicin				2	2	2
Mock lysate + amikacin				2	2	2
Mock lysate + kanamycin				4	4	4
Mock lysate + streptomycin				16	16	16
MH broth + gentamicin				2	2	2
MH broth + amikacin				2	2	2
MH broth + kanamycin				4	4	4
MH broth + streptomycin				16	16	16