TABLE 1.
Bacterial burden from kidneys of mice inoculated with ESBL- and non-ESBL-producing strains without antibiotic treatment
| Expt | Bacterial burden of kidneys (mean ± SE) (log10 CFU/g) or P value on day: |
||
|---|---|---|---|
| 1 | 2 | 6 | |
| 1 | |||
| ESBL (E16,a n = 23) | 3.5 ± 1.1 | 4 ± 0.8 | 2.6 ± 0.9 |
| Non-ESBL (9189,a n = 20) | 5.1 ± 0.3 | 2.3 ± 0.9 | 1.0 ± 1.3 |
| P | 0.18 | 0.18 | 0.63 |
| 2 | |||
| ESBL (E10,a n = 18) | 5.2 ± 1.2 | 3.9 ± 1 | 4.8 ± 0.5 |
| Non-ESBL (9142,a n = 14) | 4 ± 0.8 | 5.4 ± 0.5 | 3.9 ± 1.4 |
| P | 0.45 | 0.23 | 0.50 |
| 3 | |||
| ESBL (E94,a n = 21) | 2.3 ± 1.2 | 2.9 ± 1 | 2 ± 1 |
| Non-ESBL (BRA,a n = 21) | 4.3 ± 1.1 | 3.1 ± 0.9 | 3.5 ± 0.9 |
| P | 0.25 | 0.87 | 0.31 |
a
Different ESBL and non-ESBL clinical isolates. ESBL-producing strains were resistant to ceftriaxone (E10, 4 μg/ml; E16 and E94, >64 μg/ml) in contrast to non-ESBL-producing strains (all ≤1 μg/ml).