FIG 2.
Structural pharmacokinetic model. VELF, volume of distribution in lung compartment; Faero, fraction of the aerosol dose that reaches systemic circulation; CLOUT_CMS, clearance of CMS from central to lung compartments; CLIN_CMS, clearance of CMS from lung to central compartments; CLps_CMS, clearance of CMS presystemic conversion in colistin; CLOUT_COLI, clearance of colistin from central to lung compartments; CLIN_COLI, clearance of colistin from lung to central compartments; VCMS, volume of distribution of CMS; CLR_CMS, renal clearance of CMS; CLNR_CMS, nonrenal clearance of CMS; VCOL, volume of distribution of colistin; CLCOL, total clearance of colistin; fm, fraction of the CMS dose not excreted unchanged that is converted into colistin.