TABLE 3.
Estimated population pharmacokinetic parameters of CMS and colistin for the final model based on the data from the 12 patients of the current study
| Drug by sample type | Description | Parameter | Units | Typical value (RSE%) | IIV %CVa (RSE%) | IOV %CVb (RSE%) |
|---|---|---|---|---|---|---|
| Lung | ||||||
| CMS | Fraction of the dose that reaches the ELF | Faero | 0.09 (26) | 91 (43) | ||
| Clearance of CMS from lung to plasma | CLIN_CMS | μl/min | 15.1 (31) | 57 (52) | ||
| Clearance of CMS from plasma to lung | CLOUT_CMS | μl/min | 6.0 (90) | 128 (67) | ||
| Presystemic clearance of CMS to colistin | CLps_CMS | μl/min | 2.6 (37) | 108 (50) | ||
| CMS and colistin | Epithelial lining fluid vol | VELF | ml | 1.2 (0.24) | ||
| Colistin | Clearance of colistin from lung to plasma | CLIN_COL | μl/min | 9.8 (31) | 75 (73) | |
| Clearance of colistin from plasma to lung | CLOUT_COL | μl/min | 12.7 (58) | 107 (81) | ||
| Plasma | ||||||
| CMS | Vol of distribution of CMS | VCMS | Liters | 15.3 (12) | 38 (47) | |
| Renal clearance of CMS | CLR_CMS | ml/min | 64.6 (6.8) | 93 (55) | 61 (40) | |
| Nonrenal clearance of CMS | CLNR_CMS | ml/min | 46.3 (0.06) | |||
| Colistin | Apparent vol of distribution of colistin | VCOL/fm | Liters | 13.7 (15) | 44 (58) | |
| Apparent total clearance of colistin | CLCOL/fm | ml/min | 53.1 (8.4) | 38 (74) | 42 (46) |
a
IIV %CV, interindividual variability (expressed as a coefficient of variation).
b
IOV %CV, interoccasion variability (expressed as a coefficient of variation).