FIG 1.

Effects of SXT on different M. tuberculosis isolates. (a) MIC distribution of SXT (trimethoprim-sulfamethoxazole) for the M. tuberculosis isolates (n = 84) tested using Middlebrook 7H10 medium, shown by bars shaded as follows: non-MDR/XDR-TB (gray), XDR-TB (black), and MDR-TB (hatched). (b) Extracellular growth inhibition of M. tuberculosis H37Rv-lux. Mycobacterial growth inhibition following antibiotic exposure in concentration gradients of trimethoprim (TMP), sulfamethoxazole (SMX), and TMP and SMX in combination (mg/liter). The black horizontal line indicates MIC₅₀, and the gray line indicates MIC₉₀. (c) Intracellular effects of different concentrations of sulfamethoxazole against M. tuberculosis H37Rv-lux in a THP-1 macrophage model. The black horizontal line indicates MIC₅₀, and the gray line indicates MIC₉₀. Error bars show standard deviations.