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Individual hematologic profiles. (A) Reticulocytes as percentages of total red blood cell counts following 7 days of oral dosing at 4.5 mg/kg/day in 6 healthy animals dosed with (+)-PQ or (−)-PQ and 1 vehicle control (CTRL). (B) Percent methemoglobin levels at 1.3, 3.0, and 4.5 mg/kg/day. Note that enantiomers were switched to opposite groups between 3.0 and 4.5 mg/kg/day.
