TABLE 1.

Radical curative activity of primaquine enantiomers in 10 rhesus monkeys infected with P. cynomolgi malaria

Compound	Daily dosea (mg base/kg)	Parasitemia at treatment (1/2)b	No. of days to parasite clearance	No. of days to relapse	Activity (no. of animals undergoing radical cure/no. treated)
(+)-Primaquine	1.3	180,190	3		2/2
		55,808	2
	0.6	36,515	2		1/2
		8,291	2	36
(−)-Primaquine	1.3	312,040	3		2/2
		12,077	2
	0.6	16,662	2		2/2
		4,403	2
Control	CQ only	4,635	2	11	0/2
		8,544	3	11

^aAdministered for 7 days in combination with 10 mg chloroquine base/kg of body weight.

^b1/2, animal 1/animal 2.