TABLE 3.

Mean percent changes in pharmacodynamic variables of interest from baseline after 7 days of dosing at escalating doses

Dose and change measured	Mean % change (SD)
	(−)-PQ	(+)-PQ
1.3 mg/kg/day
Hgb decrease	1.01 (1.75)	5.24 (2.50)
Rectic increase	1.56 (2.69)	28.5 (21.1)
MetHgb increase	29.2 (11.8)	178 (122)
ALT increase	36.6 (12.7)	28.3 (24.7)
3.0 mg/kg/day
Hgb decrease	2.49 (3.00)	6.97 (3.00)
Rectic increase	19.0 (20.0)	59 (20.5)
MetHgb increase	94.1 (43.2)	237 (82.0)
ALT increase	69.2 (44.5)	54.2 (19.0)
4.5 mg/kg/day
Hgb decrease	6.47 (4.11)	5.34 (3.30)
Rectic increase	104 (38.0)	126 (87.5)
MetHgb increase	157 (194)	149 (28.2)
ALT increase	5,289 (4921)	158 (44.4)