TABLE 1.
At 5 days postchallenge, prophylactic administration of GCV reduces the liver pathology induced by i.v. Ad5 challenge in immunosuppressed hamsters
| Group | Lesion | No. of animals affected/total no. tested | Mean (range) severitya | Distribution |
|---|---|---|---|---|
| Vehicle-vehicle | 0/5 | NAb | NA | |
| Vehicle-GCV low | 0/5 | NA | NA | |
| Vehicle-GCV high | 0/5 | NA | NA | |
| Ad5-vehicle | Inflammation | 4/5 | 2.5 (1–3) | Multifocal |
| Ad5-vehicle | Decreased hepatocellular vacuolization | 5/5 | 4 (4) | Diffuse |
| Ad5-vehicle | Hepatocellular necrosis | 1/5 | 0.6 (0–3) | Multifocal |
| Ad5-GCV low | Inflammation | 4/5 | 2.2 (2–3) | Multifocal |
| Ad5-GCV low | Decreased hepatocellular vacuolization | 0/5 | NA | NA |
| Ad5-GCV low | Hepatocellular necrosis | 0/5 | NA | NA |
| Ad5-GCV high | Inflammation | 1/5 | 0.4 (0–2) | Multifocal |
| Ad5-GCV high | Decreased hepatocellular vacuolization | 1/5 | 0.4 (0–2) | Diffuse |
| Hepatocellular necrosis | 0/5 | NA | NA | |
| Ad5-BCV | Inflammation | 0/5 | NA | NA |
| Decreased hepatocellular vacuolization | 2/5 | 0.8 (0–2) | Multifocal | |
| Hepatocellular necrosis | 0/5 | NA | NA |
a
Severity scores were as follows: 0, no specific microscopic findings; 1, minimal microscopic findings; 2, mild microscopic findings; 3, moderate microscopic findings; 4, marked microscopic findings.
b
NA, not applicable.