TABLE 4.
Serum chemistry profiles in mice treated with FA-nanoATV/r (20 mg/kg, intramuscularly) weekly and biweekly for 70 days (n = 5)
| Serum component (U)a | Normal rangeb | Mean ± SEM for FA-nanoATV/r |
|---|---|---|
| AMY (U/liter) | 483–3,240 | 841.0 ± 100.4 |
| ALT (U/liter) | 17–77 | 34.9 ± 8.3 |
| ALP (U/liter) | 35–222 | 86.7 ± 17.9 |
| Total bilirubin (phosphate units in mg/dl) | 0.0–0.9 | 1.0 ± 0.1 |
| Glucose (phosphate units in mg/dl) | 140–263 | 203.6 ± 35.5 |
| Total protein (g/dl) | 3.9–6.4 | 6.4 ± 1.2 |
| Creatinine (phosphate units in mg/dl) | 0.20–0.90 | 0.8 ± 0.2 |
| Calcium (phosphate units in mg/dl) | 6.0–13.0 | 11.6 ± 1.7 |
| BUN (phosphate units in mg/dl) | 9–33 | 14.6 ± 2.1 |
| Albumin (g/dl) | 2.5–4.6 | 3.0 ± 1.0 |
| Sodium (mmol/liter) | 110–195 | 126.3 ± 3.9 |
| Potassium (mmol/liter) | 4.0–10.5 | 6.5 ± 0.4 |
| Serum globulin (g/dl) | 1.9 ± 1.1 |
a
Abbreviations: AMY, amylase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; BUN, blood urea nitrogen.
b
Values obtained from Jackson Labs (http://phenome.jax.org/db/q?rtn=projects/details&sym=Eumorphia1&mlistmode=strainvalues&reqstrainid=5).