Table 1.
Baseline characteristics of the infant cohort by cardiac diagnosis*
| Congenital heart disease |
|||||||
|---|---|---|---|---|---|---|---|
| Total (n = 730) |
Repaired (n = 194) |
Unrepaired, on PGE (n = 113) |
Unrepaired, no PGE (n = 155) |
CMP (n = 224) |
Other (n = 44) |
P value | |
| Recipient age (mo) | 3.8 (1.7–6.6) | 4.7 (1.7–7.4) | 1.5 (0.7–2.7) | 2.8 (1.3–4.6) | 5.9 (3.7–8.4) | 5.0 (2.3–7.7) | <.001 |
| Recipient weight (kg) | 4.7 (3.6–6.0) | 4.9 (3.6–6.2) | 3.6 (3.2–4.3) | 4.1 (3.4–5.0) | 5.6 (4.7–6.8) | 5.0 (4.1–6.2) | <.001 |
| Donor weight (kg) | 7.0 (5.0–10.0) | 7.0 (5.3–10.0) | 6.0 (4.0–8.0) | 6.0 (4.4–8.6) | 7.7 (6.0–11.0) | 7.0 (5.8–10.0) | <.001 |
| Donor/recipient weight ratio | 1.5 (1.1–1.9) | 1.5 (1.2–1.9) | 1.6 (1.1–2.0) | 1.5 (1.1–2.0) | 1.4 (1.1–1.8) | 1.5 (1.1–2.0) | .30 |
| Recipient BSA (kg/m2) | 0.27 (0.23–0.32) | 0.28 (0.23–0.33) | 0.23 (0.21–0.26) | 0.24 (0.21–0.28) | 0.31 (0.27–0.35) | 0.28 (0.25–0.33) | <.001 |
| Donor BSA | 0.35 (0.28–0.44) | 0.36 (0.29–0.45) | 0.31 (0.24–0.38) | 0.32 (0.25–0.41) | 0.38 (0.31–0.49) | 0.35 (0.31–0.48) | <.001 |
| Donor/recipient BSA ratio | 1.3 (1.08–1.57) | 1.30 (1.11–1.56) | 1.35 (1.07–1.66) | 1.35 (1.07–1.59) | 1.26 (1.07–1.51) | 1.26 (1.1–1.6) | .41 |
| Female sex | 331 (45%) | 71 (37%) | 40 (35%) | 67 (43%) | 132 (59%) | 21 (48%) | <.001 |
| Nonwhite race | 265 (36%) | 62 (32%) | 41 (36%) | 54 (35%) | 93 (42%) | 15 (34%) | .35 |
| Blood type O | 326 (45%) | 82 (42%) | 51 (45%) | 69 (45%) | 102 (46%) | 22 (50%) | .90 |
| PRA > 10% | 42 (14%) | 16 (22%) | 7 (14%) | 6 (9%) | 11 (12%) | 2 (13%) | .28 |
| ABO-incompatible | 54 (7%) | 21 (11%) | 8 (7%) | 12 (8%) | 9 (4%) | 4 (9%) | .10 |
| ECMO | 94 (13%) | 51 (26%) | 2 (2%) | 8 (5%) | 27 (12%) | 6 (14%) | <.001 |
| Ventilator | 213 (29%) | 63 (32%) | 31 (27%) | 40 (26%) | 66 (29%) | 13 (30%) | <.001 |
| Neither ECMO nor ventilator | 423 (58%) | 80 (41%) | 80 (71%) | 107 (69%) | 131 (58%) | 25 (57%) | <.001 |
| VAD | 22 (3%) | 0 (0%) | 1 (1%) | 2 (1%) | 16 (7%) | 3 (7%) | <.001 |
| PGE | 120 (16%) | 5 (3%) | 113 (100%) | 0 (0%) | 1 (< 1%) | 1 (2%) | <.001 |
| Dialysis | 20 (3%) | 13 (7%) | 1 (1%) | 1 (1%) | 3 (1%) | 2 (5%) | .002 |
| Creatinine clearance < 40 mL · min−1 · 1.73 m−2 |
141 (20%) | 41 (22%) | 28 (25%) | 35 (24%) | 31 (15%) | 6 (14%) | .10 |
| BSI within 2 wk before transplant |
212 (31%) | 74 (40%) | 31 (28%) | 33 (22%) | 63 (30%) | 11 (28%) | .01 |
| Prior sternotomy | 101 (32%) | 86 (100%) | 0 (0%) | 0 (0%) | 7 (7%) | 8 (47%) | <.001 |
PGE, Prostaglandin E; CMP, cardiomyopathy; BSA, body surface area; PRA, panel of reactive antibodies; ECMO, extracorporeal membrane oxygenation; VAD, ventricular assist device; BSI, bloodstream infection.
*
All clinical variables defined at the time of heart transplantation. Total number of patients varies for each row due to incomplete data entry.