Fig. 4.

A Pareto chart showing both the size and direction of each input parameter as related to the output response. Treatment onset, dose, and treatment duration, as indicated by the hollow bars, were the terms included in the model space, whereas the four solid bars, representing the three two-factor interactions and the one three-factor interaction, were excluded from the model and applied to the error. The top seven most influential factors or interactions in decreasing order are labeled 1 through 7. A, B, and C are labeled, as these are the most important factors. Treatment onset showed the largest effect, followed by dose and then treatment duration. The tip of the onset bar extends beyond the t-value limit of 2.00856, implying that this effect was significant to the model space. Orange bars depict positive effects, whereas blue bars represent negative effects.