TABLE I.

Summary Design-of-Experiments Modeling Results^*

Outcome Response	Applied Transformation	Model Terms	Effect	P Value	Coefficient of Determination (r2)
Maximum yield torque (N-mm)	Square root	Model		0.0168†	0.183
		Dose	Negative	0.1109
		Onset	Positive	0.0125†
		Duration	Positive	0.1409
		Curvature	Nonsignificant	0.7692
Tissue mineral density (mg HA/cm3)	None	Model		0.0391†	0.211
		Dose	Positive	0.9499
		Onset	Negative	0.0050†
		Duration	Positive	0.8046
		Dose and onset	Negative	0.2006
		Dose and duration	Positive	0.1695
		Curvature	Significant	0.0252†
Minimum torsional rigidity (kN-mm2)	Logarithmic	Model		0.0080†	0.172
		Dose	Negative	0.2729
		Onset	Positive	0.0035†
		Curvature	Nonsignificant	0.9125
Average torsional rigidity (kN-mm2)	Logarithmic	Model		0.0111†	0.118
		Onset	Positive	0.0114†
		Curvature	Nonsignificant	0.5544

^*In each model, five outcomes are reported: the applied transformation (if needed) to help stabilize the variance, the terms included in the model that satisfied the 10% weighted contribution threshold, the direction of each effect, the p value denoting the significance of each effect, and the coefficient of determination for the model. Onset = treatment onset, duration = treatment duration, and HA = hydroxyapatite.

^†Values with a dagger are significant (p < 0.05).