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. 2014 Aug 7;13:187. doi: 10.1186/1476-4598-13-187

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© Yao et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Downregulation of Pfn1 in pancreatic cancer correlates with poor patient survival. (A) QPCR analysis of Pfn1 expression in 40 pairs of pancreatic cancer tissues (T) and their corresponding adjacent non-cancerous tissues (ANT). GAPDH mRNA expression was used as an internal control. (B) Representative micrographs showing low Pfn1 expression in pancreatic cancer and high levels of cytoplasmic expression of Pfn1 in the corresponding adjacent non-cancerous tissues (Magnification, ×400). (C) Kaplan-Meier analysis of the correlation between the Pfn1 level and cancer-specific survival of pancreatic cancer patients with high (n = 37) and low (n = 35) Pfn1 expression. (D) Representative images of normal, well, moderately, and poorly differentiated tumors (Magnification, ×400).