Table 1.
Clinicopathological features and correlation with Pfn1 expression in pancreatic ductal adenocarcinoma
| Characteristics | No. | Pfn1-Low Score(-/+)(n = 35) | Pfn1-High Score(++/+++)(n = 37) | P value |
|---|---|---|---|---|
| Age (y) | 0.842a | |||
| <60 | 30 | 15 (20.8%) | 15 (20.8%) | |
| ≥60 | 42 | 20 (27.8%) | 22 (30.6%) | |
| Gender | 0.118a | |||
| Female | 25 | 9 (12.5%) | 16 (22.2%) | |
| Male | 47 | 26 (36.1%) | 21 (29.2%) | |
| Tumor size (cm) | 0.568a | |||
| <4.0 | 47 | 24 (33.3%) | 23 (32.0%) | |
| ≥4.0 | 25 | 11 (15.3%) | 14 (19.4%) | |
| Tumor differentiation | 0.001a | |||
| Well | 13 | 3 (4.2%) | 10 (13.9%) | |
| Moderate | 43 | 18 (25.0%) | 25 (34.7%) | |
| Poor | 16 | 14 (19.4%) | 2 (2.8%) | |
| Lymph node status (stage) | 0.101a | |||
| Negative (IIA) | 44 | 18 (25.0%) | 26 (36.1%) | |
| Positive (IIB) | 28 | 17 (23.6%) | 11 (15.3%) | |
| Vessel Infiltration | 0.068a | |||
| Negative | 56 | 24 (33.3%) | 32 (44.4%) | |
| Positive | 16 | 11 (15.3%) | 5 (7.0%) | |
| Nerve Infiltration | 0.683a | |||
| Negative | 17 | 9 (12.5%) | 8 (11.1%) | |
| Positive | 55 | 26 (36.1%) | 29 (40.3%) | |
| Median survival (in months) | 14.2 | 20.9 | 0.008b |
aP values were derived using Pearson chi-square tests.
bP values were derived using a log rank test.
All statistical tests are two sided.
Abbreviations: Pfn1 Profilin-1.