Table 1.
MCL and FL composite lymphomas.
| Case number | Age | Involvement | Immunohistochemistry staining | Treatment | Follow-up | Ref |
|---|---|---|---|---|---|---|
| Gender | ||||||
| 1 | 66 F | Waldeyer ring Tonsil Pharyngeal wall Lingual tonsil Nasal cavity |
MCL: CD5+, CD20+, IgD+, cyclinD1+, Bcl-2+, CD3− FL: CD2+, CD10+, Bcl-2+, Bcl-6+, CD5− |
Corticosteroid | PET scan every 3–6 months | [2] |
|
| ||||||
| 2 | M | Ocular adnexa | NA | NA | Poor prognosis mentioned | [3] |
|
| ||||||
| 3 | 84 F | Spleen | FL: CD20+, CD23+, Bcl-6+, CD5−, CD43−, Bcl-2− MCL: cyclinD1+, CD5− |
Splenectomy Patient refused additional treatment |
9 months after splenectomy, CT scan showed intra-abdominal lymphadenopathy and patient died from unknown cause 13 months later | [4] |
|
| ||||||
| 4 | 70 F | Cervical LN Inguinal LN |
CD20+, CD3−, cyclinD1− 50% of B-cell expressed CD5 (MCL) 30% of B-cell expressed CD10 (FL) |
No chemotherapy | CT of chest and abdomen showed no evidence of lymphadenopathy or hepatosplenomegaly | [5] |
|
| ||||||
| 5 | 65 M | Inguinal LN | FL: CD20+, CD79a+, CD10+, Bcl-2+, CD5−, CD230, cyclinD1−, p27+ MCL: CD20+, CD79a+, CD5+, CD10−, CD23−, cyclinD1+, p27− Interfollicular areas mostly CD5+ showing distinct cylinD1 staining |
Splenectomy | MCL caused disease progression into spleen. One year after splenectomy, it achieved stable disease | [6] |
|
| ||||||
| 6 | 58 F | Mesenteric LN Small bowel |
MCL: CD5+, CD20+, CD43+ FL: CD10+, CD20+, p27+ |
22 cycles of chemotherapy over 2 years | Complete remission | [7] |