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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Nat Genet. 2014 Sep 21;46(11):1227–1232. doi: 10.1038/ng.3095

Figure 3. H3K27me3 IHC significantly correlates with PRC2 genetic status and H3K27me3 loss characterizes progression from neurofibroma to MPNST.

Figure 3

(a) Representative H&E and H3K37me3 IHC images of NF1-associated, sporadic and radiotherapy associated MPNSTs. Scale bars: 100 μm. (b) Correlation of PRC2 genetic status by WES, RNA-seq and custom targeted sequencing and H3K27me3 IHC status. (c) Representative H&E and H3K27me3 IHC images of neurofibroma, NF1-associated MPNST, and the interface of plexiform neurofibroma transition into MPNST. (d) Distribution of PRC2 loss (blue) and PRC2 presence (red) by H3K27me3 IHC in NF1-associated, sporadic, radiotherapy-associated, and epithelioid MPNSTs, and neurofibromas. Fisher’s exact test was used to calculate the p value.