Table 1.

Factors affecting Mtiller glia reprogramming and proliferation.

Factor	Function	Animal tested	Expression following injury	Effect on Miiller glia regenerative response	Ref
Delta/Notch	Transmembrane ligand/receptor	Bird, Rodent, Fish	Induced	Stimulates in birds and mice; inhibits in fish	40,47,48,83
BMP/Smad	Secreted factor/transcription factor	Rodent	Induced	Stimulates	62
CNTF	Secreted factor	Fish	*No	Stimulates	85
Dkk	Secreted factor	Fish	Suppressed	Inhibits	63
EGF/EGFR	Secreted factor/receptor	Rodent	EGFR is induced	Stimulates	40,60,62
FGF2/FGFR/Mapk	Secreted factor, receptor, signaling	Bird, Rodent, Fish	Induced	Stimulates	47,49–52,115,122,123
Insulin/IGF1/PI3K	Secreted factor, signaling	Bird, Rodent, Fish	Induced	Stimulates	49–51,122
Glutamate	Secreted factor	Rodent	?	Stimulates	43
Hbegf/Mapk	Secreted factor, signaling	Fish	Induced	Stimulates	83
Shh	Secreted factor	Rodent	?	Stimulates	58
TGF β	Secreted factor	Rodent, Fish	Suppressed	Inhibits	61,94
Tnf α	Secreted factor	Fish	Induced	Stimulates	84
Hspd1	Heat shock protein	Fish	Induced	Stimulates	12
let-7	microRNA	Fish	Suppressed	Inhibits	10
Lin28	RNA binding protein	Fish	Induced	Stimulates	10
Mps1	Mitotic regulator	Fish	Induced	Stimulates	12
Apobec2	Putative cytosine deaminase	Fish	Induced	Stimulates	97
Ascl1	Transcription factor	Bird, Rodent, Fish	Induced in bird and fish	Stimulates	10,63,64
β-catenin	Signal transducer	Fish	Stabilized	Stimulates	63,92
Insm1a	Transcription factor	Fish	Induced	!stimulates	96
Pax6	Transcription factor	Bird, Rodent, Fish	Induced	Stimulates in fish	39,40,98
Stat3	Signal transducer and transcription factor	Fish	Induced	Stimulates	88
Six3b	Transcription factor	Fish	Induced	Stimulates	94
Tgif1	Transcription factor	Fish	Induced	Stimulates	94

^*a cntf gene has not been identified in fish.

^!stimulates MCillerglia reprogramming, but also stimulates progenitor cell cycle exit and differentiation.