Table III.
Comparison of best refinement structures submitted in CASP10 by Foldit-derived branches to the average GDT_TS value calculated over all predictions submitted by all groups.
| Prediction Target |
FOLDIT (068) |
Void Crushers (165) |
Anthropic Dreams (085) |
Contenders (341) |
wfFUIK (149) |
wfFUGT (260) |
Average of All CASP Predictions (± 1 Standard Deviation) |
|---|---|---|---|---|---|---|---|
| TR644 | 78.55 | 71.99 | 79.61 | 81.92 | 82.45 | 83.33 | 76.57±11.47 |
| TR655 | 65.86 | 67.57 | 64.00 | 69.29 | 69.00 | 64.57 | 65.08±3.74 |
| TR661 | 64.32 | 68.65 | 65.68 | NA | 65.81 | NA | 74.11±7.21 |
| TR662 | 81.00 | 83.67 | 82.00 | 83.33 | 84.00 | 83.33 | 79.29±9.40 |
| TR663 | 69.08 | 77.30 | 76.48 | NA | 54.93 | 54.93 | 60.22±12.10 |
| TR671 | 61.08 | 64.20 | 66.19 | 51.70 | 59.66 | 59.66 | 49.31±11.54 |
| TR674 | 77.65 | 77.84 | 78.98 | 78.60 | 82.01 | NA | 81.76±5.08 |
| TR679 | 67.08 | 69.72 | 69.97 | 72.24 | 69.85 | NA | 68.42±6.51 |
| TR681 | 76.57 | 74.22 | 74.48 | 73.30 | 77.22 | NA | 70.32±14.63 |
| TR688 | 69.19 | 74.32 | 72.57 | NA | 71.76 | NA | 74.18±5.37 |
| TR689 | 81.08 | 85.05 | 84.93 | 81.42 | 83.88 | NA | 83.01±7.29 |
| TR696 | 59.75 | 64.75 | 63.75 | 61.00 | 65.25 | 67.75 | 63.01±9.90 |
| TR698 | 63.23 | 64.58 | 64.92 | 61.34 | 64.71 | 65.13 | 63.12±3.44 |
| TR705 | 64.84 | 64.06 | 69.27 | 63.80 | 64.84 | 70.05 | 60.39±9.66 |
| TR708 | 78.57 | 82.65 | 81.50 | 78.32 | 85.71 | 81.00 | 82.44±3.54 |
| TR710 | 80.28 | 77.83 | 74.87 | 74.23 | 78.09 | 76.16 | 72.33±3.74 |
| TR712 | 81.18 | 86.83 | 85.22 | 82.26 | 88.04 | 86.42 | 86.65±5.90 |
| TR722 | 47.24 | 59.05 | 54.33 | 60.83 | 65.94 | 43.11 | 52.92±7.47 |
| TR723 | 83.40 | 79.01 | 83.02 | 86.45 | 86.83 | 82.82 | 82.57±4.10 |
| TR747 | 86.11 | 83.89 | 81.11 | 84.72 | 83.89 | 79.72 | 79.99±5.09 |
| TR750 | 67.44 | 66.35 | 67.17 | 68.68 | 72.67 | 71.57 | 72.88±5.76 |
| TR752 | 86.49 | 88.85 | 89.02 | 88.34 | 88.51 | 88.51 | 86.75±3.12 |
| TR754 | 73.90 | 73.90 | 75.73 | 60.66 | 71.69 | 56.25 | 70.26±7.54 |
| # Wins | 2 | 3 | 3 | 2 | 7 | 4 | 2 |
Besides the average GDT_TS value, the corresponding standard deviations are provided for each target. GDT_TS values were tabulated using the prediction center’s official results on the CASP10 webpage2. NA indicates that a structure was not submitted and evaluated for this target. Group numbers are denoted in parentheses. The best prediction for each target among these methods is bolded. Foldit-based human groups Void Crushers and Anthropic Dreams were able to refine and select the best structure among the cohort three times each, whereas FOLDIT was able to select it for two targets. In these two cases though, Foldit’s selection produced the top improvement in GDT_TS of any method in CASP10. These teams were a collaboration of citizen scientists. The WeFold branches wfFUIK selected the best structure seven times and wfFUGT four times indicating the enhanced performance of using these synergistic branches utilizing the structures refined by the citizen scientists followed by subsequent clustering, further refinement, and selection.