Table 3.
Day 42 MRD among patients with Ph+ ALL or Ph− ALL treated in the pre- and post-TKI era
| Day 42 MRD status (level) |
Ph+ ALL | Ph− ALL | ||
|---|---|---|---|---|
| Pre TKI (n = 16) |
Post TKI (n = 11) |
Pre TKI (n = 167) |
Post TKI (n= 204) |
|
| Negative (<0.01%) | 2 | 9 | 113 | 134 |
| Positive (≥0.01%) | 14* | 2 | 54 | 70 |
| (0.01%–<0.1%) | 1 | 2 | 26 | 37 |
| (0.1%–<1%) | 4 | 0 | 20 | 22 |
| (≥1% or remission failure) | 9* | 0 | 8 | 11 |
*
In one of the 14 patients MRD was not tested by flow cytometry or PCR; this patient had 17% blasts by morphology and t(9;22) (q34;q11.2) detectable by cytogenetic analysis.