Figure 4.

Alternative polyadenylation [poly(A)] (APA), site switching and gene expression levels of paracancerous (normal) and carcinoma tissues. Tandem APA sites switch index (TSI) is plotted against the logarithm of the expression level ratios between the carcinoma and paracancerous tissues. The x-axis denotes TSI, a larger positive value indicates that longer tandem untranslated regions (UTRs) are prone to be used in the carcinoma tissues. Genes with significant switching to longer (blue) or shorter (red) tandem UTRs in carcinoma tissues (FDR <0.01) are colored. The y-axis denotes the logarithm of the expression level of genes from the carcinoma tissues relative to the paracancerous tissues.