Table 1.
Body and tissue weight, trophism indexes, hematological, biochemical and inflammatory data, iron metabolism and EPO levels in young and old rats
| Young rats (n=8) | Old rats (n=7) | |
|---|---|---|
| Body and tissue weights | ||
| BW (Kg) | 0.45±0.02 | 0.68±0.02* |
| HW (g) | 1.14±0.04 | 1.49±0.05* |
| LVW (g) | 0.51±0.02 | 0.59±0.03 |
| KW (g) | 1.15±0.02 | 1.37±0.09* |
| Tissue trophy indexes | ||
| HW/BW (g/Kg) | 2.57±0.11 | 2.21±0.06* |
| LVW/HW (g/g) | 0.45±0.02 | 0.40±0.02* |
| LVW/BW (g/Kg) | 1.17±0.07 | 0.88±0.04* |
| KW/BW (g/Kg) | 2.59±0.08 | 2.03±0.14* |
| Hematological data | ||
| RBC (X 109/L) | 7.50 ±0.09 | 7.39±0.18 |
| Hematocrit (%) | 42.16±0.42 | 41.34±0.94 |
| Hemoglobin (g/dL) | 14.48±0.11 | 14.22±0.25 |
| MCV (fL) | 56.00±0.78 | 56.57±0.69 |
| MCH (pg) | 19.30±0.23 | 19.41±0.23 |
| MCHC (g/dL) | 34.35±0.21 | 34.47±0.33 |
| Reticulocytes (X 109/L) | 246.60±48.70 | 154.00±24.10*** |
| RDW (%) | 12.30±0.18 | 12.91±0.17* |
| Platelets (X103/μL) | 696.75±19.45 | 682.86±26.82 |
| WBC (103/μL) | 3.89±0.84 | 3.46±0.41 |
| Biochemical data | ||
| Glucose (mg/dL) | 174.63±7.03 | 195.57±15.92 |
| Urea (mg/dL) | 34.00±1.66 | 43.26±2.31* |
| Creatinine (mg/dL) | 0.34±0.01 | 0.42±0.02* |
| Inflammatory markers | ||
| hsCRP (μg/mL) | 228.3±39.60 | 175.80±29.60 |
| IL-6 (pg/mL) | 136.69±1.45 | 130.16±3.14 |
| INF-γ (pg/mL) | 13.67±3.04 | 24.29±2.33* |
| Iron metabolism | ||
| Iron (μ.g/dL) | 189.75±6.76 | 172.00±5.02** |
| Ferritin (ng/mL) | 1254.00±249.16 | 1906.71±92.17* |
| Transferrin (mg/dL) | 100.75±2.81 | 111.29±3.01* |
| sTfR (nmol/L) | 5.11±0.24 | 3.75±0.90 |
| Erythropoietin | ||
| EPO (ng/mL) | 5.78±0.91 | 3.09±0.42* |
*
p<0.05 vs. young rats;
**
p=0.056 vs. young rats;
***
p=0.065 vs. young rats; results are presented as mean ± s.e.m. BW: body weight; HW: heart weight; LVW: left ventricle weight; KW: Kidney weight; RBC: red blood cell; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean cell hemoglobin concentration; RDW: red blood cell distribution width; hsCRP: high sensitive C-reactive protein; IL-6: interleukin-6; INF-γ: interferon-gamma; sTfR: soluble transferrin receptor; EPO: erythropoietin.