Table 2.
Rat groups Young (n=8) Old (n=7) |
Scoring and distribution of glomerular and tubular lesions | ||||
---|---|---|---|---|---|
Absent | Mild (<25%) | Moderate (25–50%) | Severe (>50%) | ||
Glomerular Lesions | |||||
Thickening of CB | Young | 8 (100%) | 0 | 0 | 0 |
Old | 2 (28,6%) | 4 (57,1%) | 1 (14,3%) | 0 | |
Hyalinosis of the vascular pole | Young | 8 (100%) | 0 | 0 | 0 |
Old | 0 (0 %) | 7 (100%) | 0 | 0 | |
Glomerular atrophy | Young | 8 (100%) | 0 | 0 | 0 |
Old | 7 (100%) | 0 | 0 | 0 | |
Dilatation of the Bowman’s Space | Young | 8 (100%) | 0 | 0 | 0 |
Old | 5 (71,4%) | 2 (28,6%) | 0 | 0 | |
Hypercellularity | Young | 8 (100%) | 0 | 0 | 0 |
Old | 2 (28,6%) | 4 (57,1%) | 1 (14,3%) | 0 | |
Tubular Lesion | |||||
Hyaline cylinders | Young | 8 (100%) | 0 | 2 (28,5%) | 0 |
Old | 0 | 5 (71,4 %) | 0 | 0 | |
TBM irregularity | Young | 8 (100%) | 0 | 0 | 0 |
Old | 3 (42,9%) | 1 (14,3%) | 3 (42,9%) | 0 | |
Tubular calcification | Young | 8 (100%) | 0 | 0 | 0 |
Old | 7 (100%) | 0 | 0 | 0 | |
Interstitial fibrosis and tubular atrophy (IFTA) | Young | 8 (100%) | 0 | 0 | 0 |
Old | 0 | 7 (100%) | 0 | 0 | |
Interstitial Inflammatory infiltration | Young | 8 (100%) | 0 | 0 | 0 |
Old | 0 | 5(71,4%) | 2 (28,5%) | 0 | |
Vacuolar Tubular Degeneration | Young | 0 | 8 (100%) | 0 | 0 |
Old | 0 | 0 | 7 (100%) | 0 |