Table 1.
Examples of tumor-suppressor miRNAs.
| MicroRNA | Cancer typea | Function | Reference |
|---|---|---|---|
| miR-29b | AML | Represses Sp1 which resulted in c-KIT inhibition | 19, 20 |
| miR-34b/c | Lung cancer | A positive feedback between p53 and miR-34 mediates tumor suppression in human lung cancer | 21, 22 |
| miR-126 | Breast, lung, and colon cancers | Plays a critical tumor-suppressor role in tumor initiation and metastasis | 23, 24, 25, 26, 27 |
| miR-150 | AML | A critical tumor-suppressor gatekeeper in AML by targeting FLT3 and Myb | 28 |
| miR-155 | Breast cancer | Downregulates RAD51 and sensitizes cancer cells to irradiation | 29, 30 |
| miR-181a/b | AML | Their increased expression is associated with good prognosis and hinders tumor cell growth | 31, 32 |
| miR-375 | Breast cancer | Forced expression re-sensitizes cells to tamoxifen treatment | 33 |
| miR-494 | Lung cancer | Regulated by ERK1/2 it modulates proliferation and apoptosis response | 34 |
| miR-495 | AML; gastric cancer | Specifically down-regulated in MLL-rearranged AML; Shown to block migration and invasion | 35, 36 |
| miR-551a | Gastric cancer | Forced expression leads to a block in migration and invasion | 35 |
a
AML, Acute Myeloid Leukemia.