Table 2.
Examples of oncogenic miRNAs.
| MicroRNA | Cancer typea | Function | Reference |
|---|---|---|---|
| miR-9 | AML | Specifically overexpressed in MLL-rearranged AML and promotes leukemia progression | 37 |
| miR-17-92 | AML | Up-regulated in MLL-rearranged AML and targets p21 and RASSF2 | 38, 39, 40 |
| miR-21 | Breast cancer | Overexpression of miR-21 contributes to proliferation and metastasis | 41 |
| miR-27a | NSCLC | Promotes proliferation in NSCLC cells | 42 |
| miR-30a/c | RCC | Downregulation leads to increased expression of HIF2a | 43 |
| miR-126 | AML | Up-regulated in core-binding factor (CBF) leukemia | 44 |
| miR-181a/b | Breast, liver and colon cancers | Promote tumorigenesis and tumor progression | 45, 46, 47 |
| miR-196a | Gastric cancer | Promoted EMT, migration and invasion | 48 |
| miR-196b | AML | Upregulated in MLL-rearranged AML and targets Fas | 49 |
| miR-421 | Gastric cancer | Marker of circulating tumor cells | 50 |
a
AML, Acute Myeloid Leukemia; NSCLC, Non-Small Cell Lung Cancer; RCC, Renal Cell Carcinomas.