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. 2014 Dec 1;9(12):e112863. doi: 10.1371/journal.pone.0112863

Figure 1. Serum 25(OH)D concentrations are associated with Breslow thickness of primary melanomas.

Figure 1

Median Breslow thickness (black horizontal line) in melanoma patients is shown (1a) (<10 ng/ml = 1.9 mm, n = 77; 10–20 ng/ml = 1.4 mm, n = 122; >20 ng/ml = 1 mm, n = 108; total n = 307; p = 0.002). 17 Patients were excluded from this cohort due to missing clinical data. Boxes represent the values within the 25th and 75th percentiles (1a). We report evidence of an inverse J-shaped curve (p = 0.033), indicating that high serum 25(OH)D concentrations (>40 ng/ml) may be associated with thicker primary melanomas as well. Median Breslow thickness and 25(OH)D serum concentration at time of diagnosis from melanoma patients is shown (<10 ng/ml = 1.9 mm [ci 95%: 1.3–2.5], n = 77; 10–20 ng/ml = 1.4 mm [ci 95%: 1.1–1.8], n = 122; 20–30 ng/ml = 1.00 mm [ci 95%: 0.73–1.5], n = 65; 30–40 ng/ml = 0.8 mm [ci 95%: 0.4–1.85], n = 31; 40–50 ng/ml = 1.155 mm [ci 95%: 0.65–2.7], n = 8; >50 ng/ml = 1.25 mm [ci 95%: 0.5–2.0], n = 4; total n = 307; p = 0.033). 17 Patients were excluded from the cohort due to missing clinical data (1b).