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. 2014 Dec 1;9(12):e113169. doi: 10.1371/journal.pone.0113169

Figure 3. Association of the genomic instability score with HR-deficiency and platinum-response in ovarian cancer.

Figure 3

(A) The distribution of score in BRCA1 hyper-methylated patients is significantly higher than that in BRCA wild-type patients. (B) The distribution of score in HR-deficient patients (including EMSY amplification cases, and PTEN, Fanconi Anemia genes, RAD genes, ATM, ATR and CHEK1/2 deficient cases) is significantly higher than that in other BRCA wild-type patients. (C) Association of the score with complete response (CR). The scores of all patients (n = 325) were divided into 12 equal intervals. The percentage of patients achieving a CR (according to the Response Evaluation Criteria in Solid Tumors) was calculated for patients in each interval and was plotted against each scoring interval in increasing order. Patients in high scoring interval show increasing likelihood of achieving CR. The dashed line represents linear regression line through the data points. (D) Same as (C) but calculating for platinum-status. 133 platinum-sensitive patients and 62 platinum-resistant patients were analyzed.