Table 1. Clinicopathologic characteristics with different BRCA1/2 status.
| Characteristic | All Cases | BRCA wild-type | BRCA1 mutation | BRCA2 mutation | BRCA1 methylation | P value |
| No. of cases | 325 | 250 | 42 | 33 | 34 | |
| Age, median [range], y | 59[34–87] | 60[34–87] | 54[40–79] | 55[38–76] | 55[40–77] | .92 |
| Tumor stage | ||||||
| II | 15 | 12 | 2 | 1 | 2 | .26 |
| III | 255 | 193 | 32 | 29 | 27 | |
| IV | 55 | 45 | 8 | 2 | 5 | |
| Missing, No. | 1 | 0 | 0 | 1 | 0 | |
| Tumor grade | ||||||
| 2 | 25 | 19 | 4 | 2 | 2 | .46 |
| 3 | 292 | 225 | 37 | 30 | 32 | |
| Missing, No. | 8 | 6 | 0 | 1 | 0 | |
| Residual tumor size, cm | ||||||
| 0 | 60 | 42 | 10 | 8 | 8 | .99 |
| <1 | 158 | 120 | 21 | 17 | 18 | |
| 1–2 | 15 | 12 | 2 | 1 | 0 | |
| >2 | 57 | 48 | 5 | 4 | 5 | |
| Missing, No. | 35 | 28 | 4 | 3 | 3 | |
| Response to chemotherapy therapy | ||||||
| CR | 193 | 140 | 28 | 25 | 22 | .55 |
| Non-CR | 132 | 110 | 14 | 8 | 12 | |
| Platinum status | ||||||
| Sensitivity | 132 | 95 | 18 | 19 | 16 | .40 |
| Resistant | 63 | 53 | 7 | 3 | 8 |
For categorical data (Tumor stage and grade, residual tumor size, response to chemotherapy therapy and platinum status), the Fisher exact test was used to calculate P value in R; for continuous variable such as age, the Wilcoxon rank sum test was used in R. Patients with debulking status “no macroscopic disease” are labeled as 0 cm in residual tumor size. Number (NO.) depicts the corresponding number of patients in each category. Missing values are excluded from the test analyses. BRCA wild-type cases do not include the BRCA1 methylation cases.