Table 2. Cox proportional hazard model using relevant pretreatment factors for patients with different BRCA1/2 mutation status.

Variables	Class	Mutation			Copy Number Variation			Score Value
		HR(95%CI)	5-Year Rate, % (95% CI)	P value	HR (95%CI)	5-Year Rate, % (95% CI)	P value	HR(95%CI)	5-Year Rate, % (95% CI)	P value
Genomic instability	Wild	1(reference)	25(19–33)		1(reference)	25(19–33)			25(19–33)
	High BRCA	0.37(0.23–0.58)	63(49–81)	<0.001	0.44(0.27–0.71)	58(42–79)	<0.001	0.44(0.29–0.69)	55(42–74)	<0.001
	Low BRCA	0.84(0.26–1.30)	28 (13–61)	0.55	0.53(0.32–0.91)	43(28–68)	0.02	0.59(0.31–1.15)	42(23–76)	0.12
Grade	G2	1(reference)	60(42–86)		1(reference)	60(42–86)			60(42–86)
	G3 and G4	1.66(0.93–2.97)	29(23–37)	0.08	1.62(0.91–2.91)	29(23–37)	0.10	1.62(0.90–2.90)	29(23–37)	0.10
Debulking	0–10 mm	1(reference)	27(21–36)		1(reference)	27(21–36)			27(21–36)
	>10 mm	1.22(0.86–1.73)	25(15–41)	0.26	1.17(0.83–1.65)	25(15–41)	0.36	1.18(0.84–1.67)	25(15–41)	0.34
Stage	II	1(reference)	49(25–96)		1(reference)	49(25–96)			49(25–96)
	III and IV	1.55(0.67–3.60)	30(25–38)	0.30	1.60(0.69–3.70)	30(25–38)	0.27	1.60(0.69–3.71)	30(25–38)	0.27
Age	>34	1.01(1.00–1.03)		0.06			0.04			0.04

Abbreviations: High/Low BRCA, BRCA mutation cases in high/low level group of mutations, CNCs or scores; HR, hazard ratio; CI, confidence interval; Debulking, residual tumor size.

Two-sided P values were calculated using Cox regression model adjusting for all the variables in the table.

Patients with debulking status “no macroscopic disease” are labeled as 0 cm.