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. 2014 Dec 1;9(12):e113183. doi: 10.1371/journal.pone.0113183

Figure 4. Post-therapy CCI-779 allows for improvement of salivary flow rates, while post-therapy chloroquine (CQ) does not have a similar effect.

Figure 4

The head and neck region of FVB mice was exposed to a single 5-Gy dose of radiation and mice received injections of vehicle, CCI-779 or CQ on days 4–8 following the initial radiation treatment. Irradiated flow rates were normalized to corresponding unirradiated controls after the radiation treatment, n≥10 per treatment group. Significant differences (p<0.05) were determined using an ANOVA followed by a post-hoc Bonferroni multiple-comparison test. Letters above treatment groups are used to signify statistical significance; treatment groups with the same letters are not significantly different from each other. Data are presented as the mean ±SEM. A.) Day 30 post-therapy CCI-779. B.) Day 60 post-therapy CCI-779. C.) Day 90 post-therapy CCI-779. D.) Day 30 post-therapy CQ. E.) Day 60 post-therapy CQ. F.) Day 90 post-therapy CQ.