Figure 1. Individuals living in malaria endemic areas carry antibodies able to disrupt rosettes.

A) 75 plasma samples derived from patients living in endemic areas were tested for their capacity to disrupt rosettes of FCR3S1.2 iRBC. B) The plasma ability to bind to the surface of FCR3S1.2 iRBC was measured by flow cytometry. Uncomplicated and severe indicate malaria patients from Cameroon while Adults indicate individuals living in an area of lower endemicity (Yunnan province, China). C) Correlation between rosette disruption and surface reactivity on FCR3S1.2 iRBC for all patients samples. In red are indicated samples that are further analyzed for peptide recognition in the peptide array.